Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 (Cys modified with M6Pn) 

Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 (Compound 24, Cys modified with M6Pn) is a mannose-6-phosphate (M6Pn)-peptide conjugate capable of binding to targeted ligands of various proteins and successfully internalizing and degrading them through M6PR. Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 can be utilized in the research of lysosomal targeting chimeras (LYTACs) based on M6Pn^[1].

3419.55

C₁₂₄H₂₃₀N₂₀O₆₃P₆S₇

O=C(CCCNC([C@H](CSCCCO[C@H]1O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O)=O)CSCCCO[C@H]4O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]4O)=O)CCCCN)=O)CSCCCO[C@H]5O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]5O)=O)CCCCN)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N)=O)=O)CSCCCO[C@H]6O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]6O)=O)CCCCN)=O)CSCCCO[C@H]7O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]7O)=O)CCCCN)=O)CSCCCO[C@H]8O[C@H](CCP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]8O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stevens CM, et al. Development of Oligomeric Mannose-6-phosphonate Conjugates for Targeted Protein Degradation. ACS Med Chem Lett. 2023;14(6):719-726. Published 2023 Mar 3.  [Content Brief]