2. Membrane Transporter/Ion Channel
  3. BCRP
  4. CCTA-1523

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity.

For research use only. We do not sell to patients.

CCTA-1523 Chemical Structure

CCTA-1523 Chemical Structure

CAS No. : 1616271-41-0

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Based on 1 publication(s) in Google Scholar

CCTA-1523 Related Antibodies

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Description

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity[1].

In Vitro

CCTA-1523 (0-1000 µM; 72 h) shows cytotoxicity for H460, H460/MX20, HEK293/pcDNA3.1, HEK/R482, HEK/R482G and HEK/R482T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCTA-1523 Related Antibodies
In Vivo

CCTA-1523 (75 mg/kg; p.o.; q3d x 6) combined with doxorubicin (HY-15142A) (1.8 mg/kg, i.p., q3d X 6) inhibits tumor growth and increases the survival time in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCR nude mice (H460/MX20 xenografts)[1]
Dosage: 75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration: P.o.;q3d x 6
Result: Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.
Molecular Weight

340.20

Formula

C16H15Cl2NO3
CAS No.
SMILES

O=C(C(Cl)Cl)NC1=CC(C2=CC=C(C(OC)=C2)OC)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCTA-1523 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCTA-15231616271-41-0CCTA1523CCTA 1523BCRPBreast cancer resistance proteinABCG2anticancercytotoxicitydoxorubicinH460/MX20 xenograftsInhibitorinhibitorinhibit

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