2. Apoptosis
  3. Apoptosis
  4. CFM-4

CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells.

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CFM-4 Chemical Structure

CFM-4 Chemical Structure

CAS No. : 331458-02-7

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10 mg USD 160 In-stock
25 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

CFM-4 Related Antibodies

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Description

CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].

Molecular Weight

405.90

Formula

C22H16ClN3OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(CC2=CC=CC=C2Cl)C3=C(C=CC=C3)C14SC(C5=CC=CC=C5)=NN4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (61.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4637 mL 12.3183 mL 24.6366 mL
5 mM 0.4927 mL 2.4637 mL 4.9273 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4637 mL 12.3183 mL 24.6366 mL 61.5915 mL
5 mM 0.4927 mL 2.4637 mL 4.9273 mL 12.3183 mL
10 mM 0.2464 mL 1.2318 mL 2.4637 mL 6.1592 mL
15 mM 0.1642 mL 0.8212 mL 1.6424 mL 4.1061 mL
20 mM 0.1232 mL 0.6159 mL 1.2318 mL 3.0796 mL
25 mM 0.0985 mL 0.4927 mL 0.9855 mL 2.4637 mL
30 mM 0.0821 mL 0.4106 mL 0.8212 mL 2.0531 mL
40 mM 0.0616 mL 0.3080 mL 0.6159 mL 1.5398 mL
50 mM 0.0493 mL 0.2464 mL 0.4927 mL 1.2318 mL
60 mM 0.0411 mL 0.2053 mL 0.4106 mL 1.0265 mL
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CFM-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFM-4331458-02-7CFM4CFM 4ApoptosisBreast cancerCell cycle and apoptosis regulatory protein (CARP)Anaphase-promoting complex (APC)HeLa cellsMDA-MB-468 cellsInhibitorinhibitorinhibit

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