2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. CP-424174

CP-424174 is a reversible inhibitor against IL-1β processing with an IC50 of 210 nM.CP-424174 indirectly inhibits NLRP3.

For research use only. We do not sell to patients.

CP-424174 Chemical Structure

CP-424174 Chemical Structure

CAS No. : 210825-31-3

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2 mg USD 166 In-stock
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Based on 1 publication(s) in Google Scholar

CP-424174 Related Antibodies

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Description

CP-424174 is a reversible inhibitor against IL-1β processing with an IC50 of 210 nM.CP-424174 indirectly inhibits NLRP3[1].

Molecular Weight

452.99

Formula

C22H29ClN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=CC(C(O)(C)C)=C1)(NC(NC2=C(C=C(C=C2C(C)C)Cl)C(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (275.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2076 mL 11.0378 mL 22.0755 mL
5 mM 0.4415 mL 2.2076 mL 4.4151 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2076 mL 11.0378 mL 22.0755 mL 55.1889 mL
5 mM 0.4415 mL 2.2076 mL 4.4151 mL 11.0378 mL
10 mM 0.2208 mL 1.1038 mL 2.2076 mL 5.5189 mL
15 mM 0.1472 mL 0.7359 mL 1.4717 mL 3.6793 mL
20 mM 0.1104 mL 0.5519 mL 1.1038 mL 2.7594 mL
25 mM 0.0883 mL 0.4415 mL 0.8830 mL 2.2076 mL
30 mM 0.0736 mL 0.3679 mL 0.7359 mL 1.8396 mL
40 mM 0.0552 mL 0.2759 mL 0.5519 mL 1.3797 mL
50 mM 0.0442 mL 0.2208 mL 0.4415 mL 1.1038 mL
60 mM 0.0368 mL 0.1840 mL 0.3679 mL 0.9198 mL
80 mM 0.0276 mL 0.1380 mL 0.2759 mL 0.6899 mL
100 mM 0.0221 mL 0.1104 mL 0.2208 mL 0.5519 mL
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CP-424174 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-424174210825-31-3CP424174CP 424174NOD-like Receptor (NLR)IL-1βNLRP3InflammasomeInhibitorinhibitorinhibit

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