2. PROTAC
  3. Ligands for E3 Ligase
  4. DCAF1 binder 1

DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD).

For research use only. We do not sell to patients.

DCAF1 binder 1 Chemical Structure

DCAF1 binder 1 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1394 In-stock
Solution
10 mM * 1 mL in DMSO USD 1394 In-stock
Solid
1 mg USD 500 In-stock
5 mg USD 1250 In-stock
10 mg USD 2300 In-stock
50 mg USD 5500 In-stock
100 mg USD 8800 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD)[1].

Molecular Weight

507.07

Formula

C28H35ClN6O
Appearance

Solid

Color

White to off-white

SMILES

NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=C1C=CC(N5CCN(CC5)C(C)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (98.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9721 mL 9.8606 mL 19.7211 mL
5 mM 0.3944 mL 1.9721 mL 3.9442 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9721 mL 9.8606 mL 19.7211 mL 49.3029 mL
5 mM 0.3944 mL 1.9721 mL 3.9442 mL 9.8606 mL
10 mM 0.1972 mL 0.9861 mL 1.9721 mL 4.9303 mL
15 mM 0.1315 mL 0.6574 mL 1.3147 mL 3.2869 mL
20 mM 0.0986 mL 0.4930 mL 0.9861 mL 2.4651 mL
25 mM 0.0789 mL 0.3944 mL 0.7888 mL 1.9721 mL
30 mM 0.0657 mL 0.3287 mL 0.6574 mL 1.6434 mL
40 mM 0.0493 mL 0.2465 mL 0.4930 mL 1.2326 mL
50 mM 0.0394 mL 0.1972 mL 0.3944 mL 0.9861 mL
60 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.8217 mL
80 mM 0.0247 mL 0.1233 mL 0.2465 mL 0.6163 mL
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DCAF1 binder 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCAF1 binder 1Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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