2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis
  4. DHODH-IN-26

DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis.

For research use only. We do not sell to patients.

DHODH-IN-26 Chemical Structure

DHODH-IN-26 Chemical Structure

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DHODH-IN-26 Related Antibodies

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Description

DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis[1].

In Vitro

DHODH-IN-26 (compound B2) (0.01-100 μM, 72 h) inhibits cell growth of 4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells[1].
DHODH-IN-26 (50 and 100 nM) inhibits colony formation in B16F10 and A375 cells[1].
DHODH-IN-26 (50 and 100 nM, 48 h) decreases the expression of PD-L1 in B16F10 and A375 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-26 Related Antibodies

Cell Viability Assay[1]

Cell Line: 4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells
Concentration: 0.01, 0.1, 1, 10 and100 μM
Incubation Time: 72 h
Result: Inhibited cell growth.

Western Blot Analysis[1]

Cell Line: B16F10 and A375 cells
Concentration: 50 and 100 nM
Incubation Time: 48 h
Result: Decreased the expression of PD-L1.
In Vivo

DHODH-IN-26 (compound B2) (intraperitoneal injection, 50 mg/kg for 14 days) inhibits tumor growth in B16F10 xenograft model in C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 xenograft model in C57BL/6 mice[1]
Dosage: 50 mg/kg
Administration: I.p.; for 14 days
Result: Reduced tumor volume.
Molecular Weight

787.63

Formula

C44H34BrF2N2O3P
SMILES

CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C=C3)C4=CC=C(C=C4F)NC(CC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O)C(O)=O.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DHODH-IN-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-26Dihydroorotate DehydrogenaseReactive Oxygen SpeciesFerroptosisDHODHmelanomaB16F10A375reactive oxygen speciesferroptosislipid peroxidationInhibitorinhibitorinhibit

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