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  4. E3 ligase Ligand 24

E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation.

For research use only. We do not sell to patients.

E3 ligase Ligand 24 Chemical Structure

E3 ligase Ligand 24 Chemical Structure

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E3 ligase Ligand 24 Related Antibodies

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Description

E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation[1].

In Vitro

E3 ligase ligand 24 (5μM; 24h) effectively degrades BRD4 protein in HEK293 cells expressing HiBiT-tagged BRD4, and this degradation is not mediated by DCAF15.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E3 ligase Ligand 24 Related Antibodies
Molecular Weight

517.43

Formula

C21H26Cl2N4O5S
SMILES

CC1=C(C(N2CCC(C(NC)=O)CC2)=O)OC(S(=O)(NC3=CC=C(Cl)C4=C(Cl)CNC43)=O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E3 ligase Ligand 24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand 24OthersPROTAC Component， DCAF15 Targeting， Protein DegradationInhibitorinhibitorinhibit

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E3 ligase Ligand 24
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