2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Phosphodiesterase (PDE) STING
  4. Enpp-1-IN-19

Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence.

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Enpp-1-IN-19 Chemical Structure

Enpp-1-IN-19 Chemical Structure

CAS No. : 2738583-25-8

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5 mg USD 340 In-stock
10 mg USD 540 In-stock
25 mg USD 1100 In-stock
50 mg USD 1760 In-stock
100 mg USD 2800 In-stock
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Based on 1 publication(s) in Google Scholar

Enpp-1-IN-19 Related Antibodies

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Description

Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].

IC50 & Target

ENPP1[1]
Molecular Weight

344.39

Formula

C16H16N4O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=CC=C2C(CC3=CC=C(NS(=O)(N)=O)C=C3)=NN1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (362.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9037 mL 14.5184 mL 29.0368 mL
5 mM 0.5807 mL 2.9037 mL 5.8074 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9037 mL 14.5184 mL 29.0368 mL 72.5921 mL
5 mM 0.5807 mL 2.9037 mL 5.8074 mL 14.5184 mL
10 mM 0.2904 mL 1.4518 mL 2.9037 mL 7.2592 mL
15 mM 0.1936 mL 0.9679 mL 1.9358 mL 4.8395 mL
20 mM 0.1452 mL 0.7259 mL 1.4518 mL 3.6296 mL
25 mM 0.1161 mL 0.5807 mL 1.1615 mL 2.9037 mL
30 mM 0.0968 mL 0.4839 mL 0.9679 mL 2.4197 mL
40 mM 0.0726 mL 0.3630 mL 0.7259 mL 1.8148 mL
50 mM 0.0581 mL 0.2904 mL 0.5807 mL 1.4518 mL
60 mM 0.0484 mL 0.2420 mL 0.4839 mL 1.2099 mL
80 mM 0.0363 mL 0.1815 mL 0.3630 mL 0.9074 mL
100 mM 0.0290 mL 0.1452 mL 0.2904 mL 0.7259 mL
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Enpp-1-IN-19 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enpp-1-IN-192738583-25-8Phosphodiesterase (PDE)STINGStimulator of Interferon GenesTMEM173MITAERISMPYSorally activeInhibitorinhibitorinhibit

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