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  4. Fluplatin

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity.

For research use only. We do not sell to patients.

Fluplatin Chemical Structure

Fluplatin Chemical Structure

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Fluplatin Related Antibodies

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Description

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity[1].

In Vitro

The IC50 values of Fluplatin against H1975, A549 and A549/DDP cells were 2.24, 4.57 and 4.51 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluplatin Related Antibodies
In Vivo

Fluplatin (10.49 mg/kg, tail vein injection once every three days, a total of 5 times) shows better antitumor activity in H1975 cell subcutaneous tumor model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H1975 tumor-bearing mouse model[1]
Dosage: 10.49 mg/kg
Administration: Tail vein injection, once every three days, a total of 5 times
Result: Upregulated the expression of cleaved caspase-3.
Reduced the cholesterol level in tumor tissue.
Molecular Weight

1050.06

Formula

C48H56F2N4O8Pt
SMILES

FC1=CC=C(C=C1)C2=C(N(C3=C2C=CC=C3)C(C)C)/C=C/C(CC(CC(O[Pt]([NH3])(OC(CC(CC(/C=C/C4=C(C5=C(N4C(C)C)C=CC=C5)C6=CC=C(C=C6)F)O)O)=O)[NH3])=O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fluplatin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FluplatinOthersprodrugcisplatinfluvastatinantitumorInhibitorinhibitorinhibit

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HY-162410
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