2. Gene
  3. PDIA6 - protein disulfide isomerase family A member 6 Gene

PDIA6 - protein disulfide isomerase family A member 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as P5; ERP5; TXNDC7

Gene ID: 10130 | Gene type: protein coding

About PDIA6

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,783,391-10,837,712 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues, 13 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 159.7), placenta (RPKM 70.6) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

PDIA6 Products(5)

mRNA Protein Name
NM_001282704.2 NP_001269633.1 protein disulfide-isomerase A6 isoform a
NM_001282705.2 NP_001269634.1 protein disulfide-isomerase A6 isoform b
NM_001282706.2 NP_001269635.1 protein disulfide-isomerase A6 isoform c
NM_001282707.2 NP_001269636.1 protein disulfide-isomerase A6 isoform e precursor
NM_005742.4 NP_005733.1 protein disulfide-isomerase A6 isoform d precursor

PDIA6 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (27 - 126)

Thioredoxin

Thioredoxin: Thioredoxin (162 - 263)

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  • 440 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A6

ER protein 5

Recombinant PDIA6 Proteins

Cat. No. Product Name Accession Purity
HY-P71193 PDIA6 Protein, Human (HEK293, His) Q15084 (L20-L440) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122895 E64FC26 98.10% Unkown
HY-122895A (E/Z)-E64FC26 98.09% Unkown
HY-RS10271 PDIA6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDIA6 VGNC VGNC:75895
Mus musculus PDIA6 MGD MGI:1919103
Bos taurus PDIA6 VGNC VGNC:32700
Canis familiaris PDIA6 VGNC VGNC:103696
Felis catus PDIA6 VGNC VGNC:64086
Rattus norvegicus PDIA6 RGD RGD:628688
Others PDIA6 NCBI