CDK5 - cyclin dependent kinase 5 Gene

Homo sapiens

Also known as LIS7; PSSALRE

Gene ID: 1020 | Gene type: protein coding

About CDK5

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,053,815-151,057,897 (from NCBI)

This gene has 5 transcripts (splice variants), 167 orthologues, 26 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 18.5), adrenal (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and Apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

CDK5 Products(2)

mRNA	Protein	Name
NM_004935.4	NP_004926.1	cyclin-dependent kinase 5 isoform 1
NM_001164410.3	NP_001157882.1	cyclin-dependent kinase 5 isoform 2

CDK5 Protein Structure

Pkinase

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 5

TPKII catalytic subunit	cell division protein kinase 5
cyclin-dependent-like kinase 5	epididymis secretory sperm binding protein
protein kinase CDK5 splicing	serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit

Recombinant CDK5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72298	CDK5 Protein, Human (P.pastoris, His)	Q00535 (M1-P292)	≥95%

Related Diseases

Diseases

Alias

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diabetes Mellitus

Diabetes

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Psp
Progressive Supranuclear Ophthalmoplegia	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Mild Cognitive Impairment

Lissencephaly 7 With Cerebellar Hypoplasia

LIS7	Lissencephaly 7, With Cerebellar Hypoplasia
Lissencephaly, Type 7, With Cerebellar Hypoplasia

Scrapie

Giant Axonal Neuropathy 2

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Pick Disease Of Brain

Pick Disease	Pick Disease Of The Brain
Lobar Atrophy Of Brain	Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions
Pick'S Disease	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Purulent Acute Otitis Media

Acute Suppurative Otitis Media	Acute Or Subacute Suppurative Otitis Media
Acute Or Subacute Purulent Otitis Media

Alzheimer Disease 9

AD9	Alzheimer'S Disease 9
Alzheimer Disease 9, Susceptibility To	Alzheimer Disease 9, Late-Onset
Alzheimer'S Disease 9, Late Onset	{Alzheimer Disease 9, Susceptibility To}

Dyslexia

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Hypothyroidism, Congenital, Nongoitrous, 6

CHNG6	Congenital Nongoitrous Hypothyroidism 6
Hypothyroidism, Congenital, Non-Goitrous, 6	Hypothyroidism, Congenital, Nongoitrous, Type 6

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Ischemia

Acute Coronary Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Cerebellar Hypoplasia

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Movement Disease

Movement Disorders

Movement Disorder

Band Heterotopia

Subcortical Band Heterotopia	Double Cortex Syndrome
Subcortical Laminar Heterotopia	Double Cortex
Band Heterotopia Of Brain	BH
Heco	Heterotopic Cortex
Familial Band Heterotopia	Dc
Dc Syndrome	Heterotopia, Subcortical Band
Sbh	Sclh
Bhy

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.96%	Yes
HY-10492	Dinaciclib	Inhibitor	99.44%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.74%	Phase 4
HY-30237	(R)-Roscovitine	Inhibitor	99.84%	Phase 2
HY-50940	AT7519	Inhibitor	99.76%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.11%	Phase 2
HY-103712B	Samuraciclib hydrochloride hydrate	Inhibitor	99.08%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.42%	Phase 2
HY-112272	Lerociclib	Inhibitor	/	Phase 2
HY-10012	AZD-5438	Inhibitor	99.85%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.84%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.87%	Phase 1
HY-50940A	AT7519 TFA	Inhibitor	98.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (51)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12302	Kenpaullone	Inhibitor	98.16%	Unkown
HY-15154	NG 52	Inhibitor	99.97%	Unkown
HY-11009	CGP60474	Inhibitor	99.23%	Unkown
HY-10014	R547	Inhibitor	99.57%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	98.06%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.21%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.30%	Unkown
HY-123772	CDK5 inhibitor 20-223	Inhibitor	99.78%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.80%	Unkown
HY-18299	Purvalanol B	Inhibitor	≥97.0%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	98.95%	Unkown
HY-W011428	Olomoucine	Inhibitor	99.78%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-144117	GFB-12811	Inhibitor	98.00%	Unkown
HY-107419	NU6140	Inhibitor	99.07%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.91%	Unkown
HY-108359	Alsterpaullone	Inhibitor	98.38%	Unkown
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Unkown
HY-145694	CDK5-IN-3	Inhibitor	98.00%	Unkown
HY-117025A	Manzamine A hydrochloride	Inhibitor	99.66%	Unkown
HY-103221	MeBIO	Inhibitor	≥98.0%	Unkown
HY-154851	GSK-3 inhibitor 3	Inhibitor	98.72%	Unkown
HY-121035	7BIO	Inhibitor	≥98.0%	Unkown
HY-112468	PNU112455A hydrochloride	Inhibitor	99.56%	Unkown
HY-112358	GW8510	Inhibitor	99.64%	Unkown
HY-111930	5-Iodo-indirubin-3'-monoxime	Inhibitor	99.50%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-136726	CGP-82996	Inhibitor	/	Unkown
HY-14372	BS-194	Inhibitor	99.36%	Unkown
HY-103381	NSC693868	Inhibitor	≥99.0%	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	/	Unkown
HY-13461	PHA-767491	Inhibitor	/	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-103712	Samuraciclib	Inhibitor	/	Unkown
HY-112336	Aloisine RP106	Inhibitor	/	Unkown
HY-139725	CDK5-IN-1	Inhibitor	/	Unkown
HY-111931	Indirubin-3'-monoxime-5-sulphonic acid	Inhibitor	/	Unkown
HY-117025	Manzamine A	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-154852	GSK-3 inhibitor 4	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-145693	CDK5-IN-2	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-103383	(R)-DRF053 dihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDK5	VGNC	VGNC:51795
Felis catus	CDK5	VGNC	VGNC:60700
Mus musculus	CDK5	MGD	MGI:101765
Macaca mulatta	CDK5	VGNC	VGNC:80858
Rattus norvegicus	CDK5	RGD	RGD:70514
Bos taurus	CDK5	VGNC	VGNC:27127
Others	CDK5	NCBI