STAM2 - signal transducing adaptor molecule 2 Gene

Homo sapiens

Also known as Hbp; STAM2A; STAM2B

Gene ID: 10254 | Gene type: protein coding

About STAM2

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:152,116,801-152,175,763 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 10.8), thyroid (RPKM 10.4) and 25 other tissues.

Summary

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

STAM2 Products(1)

mRNA	Protein	Name
NM_005843.6	NP_005834.4	signal transducing adapter molecule 2

STAM2 Protein Structure

VHS

UIM

SH3_1

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

signal transducing adapter molecule 2

HSE1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13870	STAM2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STAM2	MGD	MGI:1929100
Felis catus	STAM2	VGNC	VGNC:65746
Canis familiaris	STAM2	VGNC	VGNC:46876
Bos taurus	STAM2	VGNC	VGNC:97314
Macaca mulatta	STAM2	VGNC	VGNC:77903
Rattus norvegicus	STAM2	RGD	RGD:1311497

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