2. Gene
  3. Gck - glucokinase Gene

Gck - glucokinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gk; GLK; HK4; HKIV; HXKP; Hlb62; MODY2; Gls006

Gene ID: 103988 | Gene type: protein coding

About Gck

Chromosome 11: 5,850,820-5,900,081 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 43 phenotypes. Biased expression in liver adult (RPKM 44.2), liver E18 (RPKM 7.5) and 1 other tissue.

Summary

Enables Glucokinase activity. Involved in calcium ion import; cellular glucose homeostasis; and positive regulation of Insulin secretion. Acts upstream of or within several processes, including carbohydrate phosphorylation; glucose homeostasis; and regulation of Insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; reproductive system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck Products(2)

mRNA Protein Name
NM_001287386.1 NP_001274315.1 hexokinase-4 isoform 2
NM_010292.5 NP_034422.2 hexokinase-4 isoform 1

Gck Protein Structure

COG5026

COG5026: cl34871 (15 - 457)

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  • 465 a.a.
Protein Preferred Names Protein Names

hexokinase-4

HK IV

hexokinase type IV

hexokinase-D

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-15489 Scriptaid 98.59% Unkown
HY-10943 GNF-7 Inhibitor 98.08% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-RS05329 GCK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05330 Gck Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05331 Gck Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gck NCBI NCBI:2645