LYPLA1 - lysophospholipase 1 Gene

Homo sapiens

Also known as APT1; LPL1; APT-1; LPL-I; hAPT1

Gene ID: 10434 | Gene type: protein coding

About LYPLA1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:54,046,367-54,101,947 (from NCBI)

This gene has 15 transcripts (splice variants), 230 orthologues and 2 paralogues. Ubiquitous expression in urinary bladder (RPKM 38.7), testis (RPKM 35.4) and 25 other tissues.

Summary

This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

LYPLA1 Products(6)

mRNA	Protein	Name
NM_001279356.2	NP_001266285.1	acyl-protein thioesterase 1 isoform 2
NM_001279357.2	NP_001266286.1	acyl-protein thioesterase 1 isoform 3
NM_001279358.2	NP_001266287.1	acyl-protein thioesterase 1 isoform 4
NM_001279359.2	NP_001266288.1	acyl-protein thioesterase 1 isoform 5
NM_001279360.2	NP_001266289.1	acyl-protein thioesterase 1 isoform 6
NM_006330.4	NP_006321.1	acyl-protein thioesterase 1 isoform 1

LYPLA1 Protein Structure

Abhydrolase_2

0
100
200
230 a.a.

Protein Preferred Names

Protein Names

acyl-protein thioesterase 1

lysoPLA I

Recombinant LYPLA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7539	APT-1/LYPLA1 Protein, Human (His)	O75608 (M1-D230)	≥95%

Related Diseases

Diseases

Alias

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100736	ML348	Inhibitor	99.96%	Unkown
HY-128035	ML-211	Inhibitor	≥97.0%	Unkown
HY-RS07921	LYPLA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LYPLA1	VGNC	VGNC:84014
Mus musculus	LYPLA1	MGD	MGI:1344588
Canis familiaris	LYPLA1	VGNC	VGNC:42890
Rattus norvegicus	LYPLA1	RGD	RGD:3025
Felis catus	LYPLA1	VGNC	VGNC:97489
Others	LYPLA1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.