AKAP3 - A-kinase anchoring protein 3 Gene

Homo sapiens

Also known as CT82; SOB1; FSP95; PRKA3; HEL159; AKAP110; AKAP 110

Gene ID: 10566 | Gene type: protein coding

About AKAP3

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,615,518-4,649,051 (from NCBI)

This gene has 6 transcripts (splice variants), 110 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 61.9).

Summary

This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]

AKAP3 Products(2)

mRNA	Protein	Name
NM_001278309.2	NP_001265238.2	A-kinase anchor protein 3
NM_006422.4	NP_006413.4	A-kinase anchor protein 3

AKAP3 Protein Structure

RII_binding_1

AKAP_110

0
200
400
600
800
853 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 3

A kinase (PRKA) anchor protein 3

Related Diseases

Diseases

Alias

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00518	AKAP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AKAP3	VGNC	VGNC:59713
Rattus norvegicus	AKAP3	RGD	RGD:1359735
Mus musculus	AKAP3	MGD	MGI:1341149
Macaca mulatta	AKAP3	VGNC	VGNC:69769
Bos taurus	AKAP3	VGNC	VGNC:25784
Canis familiaris	AKAP3	VGNC	VGNC:37756

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