GNA13 - G protein subunit alpha 13 Gene

Homo sapiens

Also known as G13; HG1N

Gene ID: 10672 | Gene type: protein coding

About GNA13

Cytogenetic location: 17q24.1 Genomic coordinates (GRCh38): 17:65,009,289-65,056,740 (from NCBI)

This gene has 2 transcripts (splice variants), 310 orthologues and 15 paralogues. Ubiquitous expression in bone marrow (RPKM 46.2), lymph node (RPKM 22.6) and 24 other tissues.

Summary

Predicted to enable D5 Dopamine Receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in several processes, including Rho protein signal transduction; activation of Phospholipase D activity; and multicellular organism aging. Predicted to act upstream of or within several processes, including branching involved in blood vessel morphogenesis; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GNA13 Products(2)

mRNA	Protein	Name
NM_001282425.2	NP_001269354.1	guanine nucleotide-binding protein subunit alpha-13 isoform 2
NM_006572.6	NP_006563.2	guanine nucleotide-binding protein subunit alpha-13 isoform 1

GNA13 Protein Structure

G-alpha

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein subunit alpha-13

g alpha-13

Related Diseases

Diseases

Alias

St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th	High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements
High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

Dendritic Cell Deficiency

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05531	GNA13 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GNA13	MGD	MGI:95768
Canis familiaris	GNA13	VGNC	VGNC:41298
Macaca mulatta	GNA13	VGNC	VGNC:73087
Felis catus	GNA13	VGNC	VGNC:62615
Rattus norvegicus	GNA13	RGD	RGD:1310221
Bos taurus	GNA13	VGNC	VGNC:29446

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