PDIA5 - protein disulfide isomerase family A member 5 Gene

Homo sapiens

Also known as PDIR

Gene ID: 10954 | Gene type: protein coding

About PDIA5

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,067,025-123,162,104 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 13 paralogues. Ubiquitous expression in placenta (RPKM 25.8), prostate (RPKM 23.2) and 24 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]

PDIA5 Products(1)

mRNA	Protein	Name
NM_006810.4	NP_006801.1	protein disulfide-isomerase A5 precursor

PDIA5 Protein Structure

Thioredoxin

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

protein disulfide-isomerase A5

protein disulfide isomerase-associated 5

Recombinant PDIA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71192	PDIA5 Protein, Human (HEK293, His)	Q14554-2 (S22-L262)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10270	PDIA5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PDIA5	VGNC	VGNC:64085
Macaca mulatta	PDIA5	VGNC	VGNC:75858
Rattus norvegicus	PDIA5	RGD	RGD:1359236
Canis familiaris	PDIA5	VGNC	VGNC:44378
Mus musculus	PDIA5	MGD	MGI:1919849
Bos taurus	PDIA5	VGNC	VGNC:32699
Others	PDIA5	NCBI

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