TDRKH - tudor and KH domain containing Gene

Homo sapiens

Also known as TDRD2

Gene ID: 11022 | Gene type: protein coding

About TDRKH

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,766,486-151,790,534 (from NCBI)

This gene has 14 transcripts (splice variants), 138 orthologues and 6 paralogues. Broad expression in testis (RPKM 11.8), brain (RPKM 4.0) and 21 other tissues.

Summary

Predicted to enable RNA binding activity. Predicted to be involved in fertilization; gamete generation; and piRNA metabolic process. Predicted to be located in mitochondrion; pi-body; and piP-body. [provided by Alliance of Genome Resources, Apr 2022]

TDRKH Products(4)

mRNA	Protein	Name
NM_001083963.1	NP_001077432.1	tudor and KH domain-containing protein isoform a
NM_001083964.1	NP_001077433.1	tudor and KH domain-containing protein isoform b
NM_001083965.2	NP_001077434.1	tudor and KH domain-containing protein isoform a
NM_006862.4	NP_006853.2	tudor and KH domain-containing protein isoform a

TDRKH Protein Structure

KH_1

TUDOR

0
100
200
300
400
500
561 a.a.

Protein Preferred Names

Protein Names

tudor and KH domain-containing protein

putative RNA binding protein

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Charcot-Marie-Tooth Hereditary Neuropathy

Distal Spinal Muscular Atrophy	Distal Hereditary Motor Neuropathy
Dhmn	Hereditary Motor/Sensory Neuropathy
Hmsn	Dsma
Distal Hereditary Motor Neuropathies	Spinal Muscular Atrophy Distal
Neuropathy, Motor, Distal, Hereditary	Charcot-Marie-Tooth Disease

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14340	TDRKH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TDRKH	RGD	RGD:1311196
Canis familiaris	TDRKH	VGNC	VGNC:47227
Felis catus	TDRKH	VGNC	VGNC:66052
Mus musculus	TDRKH	MGD	MGI:1919884
Macaca mulatta	TDRKH	VGNC	VGNC:78300
Bos taurus	TDRKH	VGNC	VGNC:55688

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