2. Gene
  3. ADPRHL1 - ADP-ribosylhydrolase like 1 Gene

ADPRHL1 - ADP-ribosylhydrolase like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARH2

Gene ID: 113622 | Gene type: protein coding

About ADPRHL1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,399,610-113,453,488 (from NCBI)

This gene has 5 transcripts (splice variants), 158 orthologues and 1 paralogue. Biased expression in heart (RPKM 98.4) and prostate (RPKM 3.2).

Summary

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]

ADPRHL1 Products(5)

mRNA Protein Name
NM_001304433.1 NP_001291362.1 inactive ADP-ribosyltransferase ARH2 isoform 3
NM_001375393.1 NP_001362322.1 inactive ADP-ribosyltransferase ARH2 isoform 3
NM_001394807.1 NP_001381736.1 inactive ADP-ribosyltransferase ARH2 isoform 4
NM_138430.5 NP_612439.2 inactive ADP-ribosyltransferase ARH2 isoform 1
NM_199162.3 NP_954631.1 inactive ADP-ribosyltransferase ARH2 isoform 2

ADPRHL1 Protein Structure

ADP_ribosyl_GH

ADP_ribosyl_GH: ADP-ribosylglycohydrolase (6 - 327)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

inactive ADP-ribosyltransferase ARH2

ADP-ribosyl-hydrolase

Related Diseases

Diseases Alias
Brain Small Vessel Disease 2

Porencephaly 2

BSVD2

Gould Syndrome 2

Porencephaly 2, Formerly

Poren2, Formerly

Poren2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00405 ADPRHL1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADPRHL1 MGD MGI:2442168
Rattus norvegicus ADPRHL1 RGD RGD:1305641