CHRNB3 - cholinergic receptor nicotinic beta 3 subunit Gene

Homo sapiens

Gene ID: 1142 | Gene type: protein coding

About CHRNB3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,697,366-42,737,407 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

CHRNB3 Products(2)

mRNA	Protein	Name
NM_000749.5	NP_000740.1	neuronal acetylcholine receptor subunit beta-3 isoform 1 precursor
NM_001347717.2	NP_001334646.1	neuronal acetylcholine receptor subunit beta-3 isoform 2

CHRNB3 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit beta-3

acetylcholine receptor, neuronal nicotinic, beta-3 subunit

Recombinant CHRNB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70056	CHRNB3 Protein, Human (HEK293, His)	Q05901 (I25-L232)	≥95%

Related Diseases

Diseases

Alias

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Compensatory Emphysema

Dystonia 6, Torsion

DYT6	Torsion Dystonia 6
Dystonia 6	Idiopathic Torsion Dystonia Of Mixed Type
Primary Dystonia, Dyt6 Type	Torsion Dystonia, Adult-Onset, Mixed Type
Dyt-Thap1	Adolescent-Onset Dystonia Of Mixed Type
Torsion Dystonia Adult Onset Mixed Type	Dyt6 Dystonia
Thap1 Dystonia	Generalized Cervical And Upper-Limb-Onset Dystonia
Adult-Onset Torsion Dystonia Mixed Type	Autosomal Dominant Torsion Dystonia 6
Dystonia-6	Torsion Dystonia Type 6
Dystonia, Type 6, Torsion

Tobacco Addiction

Nicotine Dependence	Tobacco Addiction, Susceptibility To
Nicotine Addiction	Tobacco Use Disorder
Smoking Habit	Nicotine Dependence, Protection Against
Nicotine Addiction, Protection From	Cigarette Habituation
Cigarette Habituation, Susceptibility To	Smoking Habit, Susceptibility To
Nicotine Dependence, Susceptibility To	Nicotine Addiction, Susceptibility To
Addiction, Tobacco, Susceptibility To	Compulsive Tobacco User Syndrome
Tobacco Dependence	Tobacco Dependence Syndrome
Cigarette Addiction	Cigarette Dependence
Smoking Addiction	Smokers Syndrome

Cocaine Dependence

Substance Dependence

Drug Dependence

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle	Autosomal Dominant Sleep-Related Hypermotor Epilepsy
Enfl	Benign Familial Infantile Seizures 6
Benign Familial Infantile Seizures, 6	Nocturnal Frontal Lobe Epilepsy-4
Enfl1	Epilepsy, Nocturnal Frontal Lobe, 1
Epilepsy, Nocturnal Frontal Lobe, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02676	CHRNB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHRNB3	VGNC	VGNC:39244
Rattus norvegicus	CHRNB3	RGD	RGD:621544
Felis catus	CHRNB3	VGNC	VGNC:60885
Bos taurus	CHRNB3	VGNC	VGNC:27332
Mus musculus	CHRNB3	MGD	MGI:106212
Macaca mulatta	CHRNB3	VGNC	VGNC:104445
Others	CHRNB3	NCBI

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