2. Gene
  3. Cdk6 - cyclin-dependent kinase 6 Gene

Cdk6 - cyclin-dependent kinase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 114483 | Gene type: protein coding

About Cdk6

Primary_assembly 4: 30,646,460-30,829,634 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 199 orthologues, 24 paralogues and is associated with 24 phenotypes. Biased expression in Thymus (RPKM 15.7), Kidney (RPKM 87.) and 9 other tissues.

Summary

Enables cyclin binding activity. Predicted to be involved in several processes, including negative regulation of cellular senescence; negative regulation of osteoblast differentiation; and regulation of myeloid cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of hematopoietic stem cell differentiation. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D2-CDK6 complex and mediator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Cdk6 Products(1)

mRNA Protein Name
NM_001191861.2 NP_001178790.1 cyclin-dependent kinase 6

Cdk6 Protein Structure

STKc_CDK6

STKc_CDK6: cd07862 (10 - 299)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 6

cell division protein kinase 6

Related Agents

Approval
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.96% Yes
HY-15777 Ribociclib Inhibitor 99.98% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-A0065 Palbociclib isethionate Inhibitor 99.99% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.84% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.74% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.96% Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.92% Phase 3
HY-114338 Dalpiciclib Inhibitor 99.40% Phase 3
HY-101563 GSK3326595 99.97% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-12624 Narazaciclib Inhibitor 99.12% Phase 1
HY-111361 FN-1501 Inhibitor 99.08% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
Bioactive Molecules (58)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103248 Toyocamycin Inhibitor 99.90% Unkown
HY-139450 PF-07220060 Inhibitor 99.87% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.91% Unkown
HY-111556 BSJ-03-123 Inhibitor 98.12% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-10014 R547 Inhibitor 99.57% Unkown
HY-136252 BSJ-04-132 Inhibitor 98.32% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-138946 XY028-140 Inhibitor 98.42% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.94% Unkown
HY-116035 Nimbolide Inhibitor 99.94% Unkown
HY-125835 CP-10 Inhibitor 98.22% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-16559 Riviciclib hydrochloride 99.01% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 96.02% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.01% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-129180 XY028-133 Inhibitor 98.62% Unkown
HY-15889 AMG 925 Inhibitor 98.20% Unkown
HY-148530 YX-2-107 Degrader 99.79% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.16% Unkown
HY-148063 DB0614 98.80% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.82% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 96.15% Unkown
HY-112346 RGB-286147 Inhibitor ≥98.0% Unkown
HY-15889A AMG 925 HCl Inhibitor / Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 97.01% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-136726 CGP-82996 Inhibitor / Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-131063 CDK6/9-IN-1 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-146213 CDK4/6-IN-12 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor / Unkown
HY-153336 CDK-IN-12 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-115992 CDK4/6-IN-9 Inhibitor / Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor / Unkown
HY-112418 CDK4/6-IN-18 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk6 NCBI NCBI:1021