2. Gene
  3. Acvr2a - activin receptor IIA Gene

Acvr2a - activin receptor IIA Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Acvr2; ActrIIa; TactrII

Gene ID: 11480 | Gene type: protein coding

About Acvr2a

Chromosome 2: 48,704,121-48,793,281 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 45 phenotypes. Broad expression in CNS E18 (RPKM 16.6), whole brain E14.5 (RPKM 12.4) and 25 other tissues.

Summary

Enables several functions, including BMP Receptor activity; PDZ domain binding activity; and activin binding activity. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and embryonic skeletal system development. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a Products(1)

mRNA Protein Name
NM_007396.4 NP_031422.3 activin receptor type-2A precursor

Acvr2a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 113)

STKc_ACVR2a

STKc_ACVR2a: cd14141 (195 - 484)

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  • 513 a.a.
Protein Preferred Names Protein Names

activin receptor type-2A

ACTR-IIA

activin receptor type IIA

Recombinant Acvr2a Proteins

Cat. No. Product Name Accession Purity
HY-P75562 ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) P27038 (M1-P134) ≥95%
HY-P75563 ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) P27038 (A20-P134) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99355 Bimagrumab Inhibitor 99.07% Phase 3
HY-P99590 Sotatercept 99.61% Phase 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr2a NCBI NCBI:92