2. Gene
  3. Adam10 - a disintegrin and metallopeptidase domain 10 Gene

Adam10 - a disintegrin and metallopeptidase domain 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as kuz; MADM; kuzbanian; 1700031C13Rik

Gene ID: 11487 | Gene type: protein coding

About Adam10

Chromosome 9: 70,586,279-70,687,511 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 371 orthologues, 35 paralogues and is associated with 16 phenotypes. Ubiquitous expression in liver E14 (RPKM 28.), liver E14.5 (RPKM 23.2) and 27 other tissues.

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature Enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]

Adam10 Products(1)

mRNA Protein Name
NM_007399.4 NP_031425.2 disintegrin and metalloproteinase domain-containing protein 10 preproprotein

Adam10 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: cl03265 (45 - 155)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (220 - 459)

DISIN

DISIN: smart00050 (466 - 545)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 10

a disintegrin and metalloprotease domain (ADAM) 10

kuzbanian protein homolog

mammalian disintegrin-metalloprotease

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10293 Aderbasib Inhibitor 98.09% Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115670 GW280264X Inhibitor 98.28% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-108675 PPNDS tetrasodium Inhibitor 96.39% Unkown
HY-120852 JG26 Inhibitor 98.01% Unkown
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.21% Unkown
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam10 NCBI NCBI:102