2. Gene
  3. OSBPL1A - oxysterol binding protein like 1A Gene

OSBPL1A - oxysterol binding protein like 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ORP1; ORP-1; OSBPL1B

Gene ID: 114876 | Gene type: protein coding

About OSBPL1A

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:24,162,045-24,397,824 (from NCBI)

This gene has 16 transcripts (splice variants), 312 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 18.5), fat (RPKM 17.7) and 24 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]

OSBPL1A Products(3)

mRNA Protein Name
NM_001242508.1 NP_001229437.1 oxysterol-binding protein-related protein 1 isoform 3
NM_018030.4 NP_060500.3 oxysterol-binding protein-related protein 1 isoform 1
NM_080597.4 NP_542164.2 oxysterol-binding protein-related protein 1 isoform 2

OSBPL1A Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (11 - 109)

Ank_5

Ank_5: Ankyrin repeats (many copies) (160 - 216)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (548 - 940)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 950 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein-related protein 1

OSBP-related protein 1

Related Diseases

Diseases Alias
Splenic Manifestation Of Leukemia

Splenic Leukemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09839 OSBPL1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OSBPL1A VGNC VGNC:75632
Bos taurus OSBPL1A VGNC VGNC:32460
Felis catus OSBPL1A VGNC VGNC:107713
Mus musculus OSBPL1A MGD MGI:1927551
Rattus norvegicus OSBPL1A RGD RGD:628888
Canis familiaris OSBPL1A VGNC VGNC:44153