2. Gene
  3. Parp2 - poly (ADP-ribose) polymerase family, member 2 Gene

Parp2 - poly (ADP-ribose) polymerase family, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2

Gene ID: 11546 | Gene type: protein coding

About Parp2

Chromosome 14: 51,045,298-51,058,758 forward strand.GRCm39:CM001007.3

This gene has 8 transcripts (splice variants), 185 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 2.7), liver E14 (RPKM 15.1) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Parp2 Products(1)

mRNA Protein Name
NM_009632.3 NP_033762.1 poly [ADP-ribose] polymerase 2

Parp2 Protein Structure

PLN03124

PLN03124: cl33640 (26 - 554)

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  • 559 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2

ADP-ribosyltransferase (NAD+

poly (ADP-ribose) polymerase) 2

ADP-ribosyltransferase diphtheria toxin-like 2

DNA ADP-ribosyltransferase PARP2

NAD(+) ADP-ribosyltransferase 2

poly[ADP-ribose] synthase 2

poly[ADP-ribose] synthetase 2

protein poly-ADP-ribosyltransferase PARP2

Related Agents

Approval
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10162 Olaparib Inhibitor 99.98% Yes
HY-16106 Talazoparib Inhibitor 99.89% Unkown
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.80% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.76% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-10129 Veliparib Inhibitor 99.92% Phase 3
HY-10130 Veliparib dihydrochloride Inhibitor 99.96% Phase 3
HY-132167 Saruparib Inhibitor 99.79% Phase 2
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
HY-115552 Simmiparib Inhibitor 99.51% Phase 1
Pre-clinical Phase
Bioactive Molecules (36)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-13688A PJ34 Inhibitor 98.11% Unkown
HY-13688 PJ34 hydrochloride Inhibitor 99.91% Unkown
HY-13990 NVP-TNKS656 Inhibitor 99.66% Unkown
HY-150207 RBN-3143 Inhibitor 99.24% Unkown
HY-137457 Venadaparib Inhibitor 98.11% Unkown
HY-12975 AZ6102 Inhibitor 99.65% Unkown
HY-100225 ME0328 Inhibitor 99.59% Unkown
HY-14478 UPF 1069 Inhibitor 99.10% Unkown
HY-18954 NMS-P118 Inhibitor 99.78% Unkown
HY-19351 MN-64 Inhibitor 99.73% Unkown
HY-122661 Mefuparib hydrochloride Inhibitor 98.94% Unkown
HY-108632 BYK204165 Inhibitor 98.66% Unkown
HY-10614 A-966492 Inhibitor 99.95% Unkown
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.21% Unkown
HY-148566 OUL232 Inhibitor 99.82% Unkown
HY-156419 PARP7-IN-16 Inhibitor / Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-147886 PARP1-IN-11 Inhibitor 98.58% Unkown
HY-121719 TIQ-A Inhibitor 99.65% Unkown
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.43% Unkown
HY-102035 PARP-2-IN-1 Inhibitor 99.56% Unkown
HY-105692 DR2313 Inhibitor 98.70% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.89% Unkown
HY-132297 PARP1-IN-5 Inhibitor / Unkown
HY-137457A Venadaparib hydrochloride Inhibitor / Unkown
HY-151625 PARP-2-IN-3 Inhibitor / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-145749 PARPYnD Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-155993 YCH1899 Inhibitor / Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor / Unkown
HY-105253 PARP-2/1-IN-2 Inhibitor / Unkown
HY-161606 PARP-1/2/7-IN-1 Inhibitor / Unkown
HY-149800 PARP-1-IN-3 Inhibitor 99.30% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp2 NCBI NCBI:10038