2. Gene
  3. Alox15 - arachidonate 15-lipoxygenase Gene

Alox15 - arachidonate 15-lipoxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO

Gene ID: 11687 | Gene type: protein coding

About Alox15

Chromosome 11: 70,234,978-70,242,857 reverse strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 168 orthologues, 6 paralogues and is associated with 23 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues.

Summary

Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox15 Products(1)

mRNA Protein Name
NM_009660.3 NP_033790.3 polyunsaturated fatty acid lipoxygenase ALOX15

Alox15 Protein Structure

PLAT_LOX

PLAT_LOX: cd01753 (1 - 111)

Lipoxygenase

Lipoxygenase: cl37981 (201 - 653)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX15

12-LOX

12/15-lipoxygenase

arachidonate 12-lipoxygenase, leukocyte-type

arachidonate omega-6 lipoxygenase

hepoxilin A3 synthase Alox15

linoleate 13S-lipoxygenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-143787 ALOX15-IN-1 Inhibitor 98.09% Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox15 NCBI NCBI:246