DACH2 - dachshund family transcription factor 2 Gene

Homo sapiens

Gene ID: 117154 | Gene type: protein coding

About DACH2

Cytogenetic location: Xq21.2 Genomic coordinates (GRCh38): X:86,148,451-86,832,602 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 1 paralogue. Biased expression in brain (RPKM 3.6) and kidney (RPKM 0.3).

Summary

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

DACH2 Products(3)

mRNA	Protein	Name
NM_001139514.1	NP_001132986.1	dachshund homolog 2 isoform b
NM_001139515.1	NP_001132987.1	dachshund homolog 2 isoform c
NM_053281.3	NP_444511.1	dachshund homolog 2 isoform a

DACH2 Protein Structure

Ski_Sno

0
100
200
300
400
500
599 a.a.

Protein Preferred Names

Protein Names

dachshund homolog 2

Related Diseases

Diseases

Alias

Enterobiasis

Oxyuriasis	Pinworm Infection
Enterobius Vermicularis Infection	Threadworm Infection
Oxyuris Vermicularis Infection	Enterobiosis
Pinworm	Pinworm Disease
Seatworm Infection	Enterobiasis Threadworm
Pinworm Infestation	Seatworm

Miles-Carpenter Syndrome

X-Linked Intellectual Disability, Miles-Carpenter Type	Mcs
Mental Retardation, X-Linked, Syndromic 4	Mental Retardation, X-Linked, With Congenital Contractures And Low Fingertip Arches
Mrxs4	Miles-Carpenter X-Linked Mental Retardation Syndrome

Mullerian Aplasia And Hyperandrogenism

Mullerian Duct Failure And Hyperandrogenism	Wnt4 Deficiency
Müllerian Aplasia And Hyperandrogenism	Biason-Lauber Syndrome
Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome	Mayer-Rokitansky-Küster-Hauser-Like Syndrome
Müllerian Duct Failure	Wnt4 Müllerian Aplasia
Wnt4 Müllerian Aplasia And Ovarian Dysfunction	MULLAPL
Wnt4 Mullerian Aplasia And Ovarian Dysfunction

Deafness, X-Linked 7

X-Linked External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome	DFNX7
X-Linked Deafness 7	Deafness, X-Linked, 7

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03514	DACH2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DACH2	RGD	RGD:1561687
Mus musculus	DACH2	MGD	MGI:1890446
Canis familiaris	DACH2	VGNC	VGNC:54131
Macaca mulatta	DACH2	VGNC	VGNC:71635
Bos taurus	DACH2	VGNC	VGNC:106705

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