2. Gene
  3. Xiap - X-linked inhibitor of apoptosis Gene

Xiap - X-linked inhibitor of apoptosis Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik

Gene ID: 11798 | Gene type: protein coding

About Xiap

Chromosome X: 41,148,556-41,198,533 forward strand.GRCm39:CM001013.3

This gene has 11 transcripts (splice variants), 217 orthologues, 10 paralogues and is associated with 15 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues.

Summary

The protein encoded by this gene is a member of the inhibitor of Apoptosis (IAP) family of proteins. While first identified for its role in blocking Apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks Apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Xiap Products(3)

mRNA Protein Name
NM_001301641.1 NP_001288570.1 E3 ubiquitin-protein ligase XIAP
NM_001301639.1 NP_001288568.1 E3 ubiquitin-protein ligase XIAP
NM_009688.3 NP_033818.2 E3 ubiquitin-protein ligase XIAP

Xiap Protein Structure

BIR

BIR: cd00022 (27 - 94)

BIR

BIR: smart00238 (161 - 231)

BIR

BIR: smart00238 (263 - 329)

UBA_BIRC4_8

UBA_BIRC4_8: cd14395 (368 - 417)

RING-HC_BIRC4_8

RING-HC_BIRC4_8: cd16714 (432 - 495)

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  • 496 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase XIAP

IAP homolog A

RING-type E3 ubiquitin transferase XIAP

X-linked IAP

baculoviral IAP repeat-containing protein 4

inhibitor of apoptosis protein 3

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15454 Xevinapant Antagonist 99.94% Phase 3
HY-13208 Xevinapant hydrochloride Antagonist 98.80% Phase 3
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12600 AZD5582 Antagonist 98.75% Unkown
HY-17473 Embelin Antagonist 98.75% Unkown
HY-110346 AZD5582 dihydrochloride Antagonist 98.67% Unkown
HY-151966 TD1092 Degrader 99.49% Unkown
HY-125378 SBP-0636457 Antagonist 98.42% Unkown
HY-102051 XIAP/cIAP1 antagonist-1 Inhibitor / Unkown
HY-100682 T-3256336 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xiap NCBI NCBI:331