DBX1 - developing brain homeobox 1 Gene

Homo sapiens

Also known as HLX1

Gene ID: 120237 | Gene type: protein coding

About DBX1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,156,155-20,160,475 (from NCBI)

This gene has 1 transcript (splice variant), 249 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation in spinal cord and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within ventral spinal cord interneuron specification. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

DBX1 Products(1)

mRNA	Protein	Name
NM_001029865.4	NP_001025036.2	homeobox protein DBX1

DBX1 Protein Structure

Homeobox

0
100
200
300
343 a.a.

Protein Preferred Names

Protein Names

homeobox protein DBX1

developing brain homeobox protein 1

Related Diseases

Diseases

Alias

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03555	DBX1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DBX1	VGNC	VGNC:27897
Mus musculus	DBX1	MGD	MGI:94867
Macaca mulatta	DBX1	VGNC	VGNC:100924
Canis familiaris	DBX1	VGNC	VGNC:52068
Rattus norvegicus	DBX1	RGD	RGD:1308896
Felis catus	DBX1	VGNC	VGNC:61352