2. Gene
  3. Bax - BCL2-associated X protein Gene

Bax - BCL2-associated X protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 12028 | Gene type: protein coding

About Bax

Chromosome 7: 45,111,121-45,116,322 reverse strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 206 orthologues, 10 paralogues and is associated with 27 phenotypes. Ubiquitous expression in ovary adult (RPKM 2.8), placenta adult (RPKM 19.6) and 28 other tissues.

Summary

Enables HSP70 protein binding activity; chaperone binding activity; and identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Part of Bax complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human Bax (BCL2 associated X, Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Bax Products(4)

mRNA Protein Name
NM_001411996.1 NP_001398925.1 apoptosis regulator BAX isoform 4
NM_001411994.1 NP_001398923.1 apoptosis regulator BAX isoform 2
NM_007527.4 NP_031553.1 apoptosis regulator BAX isoform 1
NM_001411995.1 NP_001398924.1 apoptosis regulator BAX isoform 3

Bax Protein Structure

bcl-2

bcl-2: TIGR00865 (4 - 191)

  • 0
  • 100
  • 192 a.a.
Protein Preferred Names Protein Names

apoptosis regulator BAX

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1192 Estradiol benzoate 99.89% Unkown
HY-B0402 Amantadine Modulator 99.90% Yes
HY-B1357 Digitoxin 99.36% Yes
HY-B0402A Amantadine hydrochloride Modulator ≥98.0% Yes
HY-B0621 Triclabendazole 98.72% Yes
HY-B0402B Amantadine sulfate Modulator / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13755 Sulforaphane Inhibitor 99.75% Phase 4
Pre-clinical Phase
Bioactive Molecules (45)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107202 Polyinosinic-polycytidylic acid 99.40% Unkown
HY-13594 Chlorin e6 97.24% Unkown
HY-103269 BAI1 Inhibitor 99.73% Unkown
HY-N0674 Dehydrocorydaline Modulator 99.77% Unkown
HY-P0081 Bax inhibitor peptide V5 Inhibitor 98.28% Unkown
HY-123054 BTSA1 Activator 99.49% Unkown
HY-N0361 Dihydrocapsaicin Modulator 99.86% Unkown
HY-B1971 Deltamethrin 99.93% Unkown
HY-120079 MSN-125 Inhibitor 99.00% Unkown
HY-13755A (R)-Sulforaphane Inhibitor 99.37% Unkown
HY-N0060B (E)-Ferulic acid Activator 99.88% Unkown
HY-13108 Bz 423 Activator 99.72% Unkown
HY-N0831 Jaceosidin Activator 99.51% Unkown
HY-N6626 Pyraclostrobin 99.91% Unkown
HY-P1928 Humanin Inhibitor ≥95.0% Unkown
HY-15341 BAM7 Activator 98.53% Unkown
HY-118948 MSN-50 Inhibitor 98.40% Unkown
HY-W082785A L6H21 Modulator 99.46% Unkown
HY-132173 GL0388 Activator 98.01% Unkown
HY-N9802 n-Butyl-β-D-fructofuranoside Activator ≥97.0% Unkown
HY-122760 Bax activator-1 Activator 98.45% Unkown
HY-108164 Aspidin BB Modulator 98.08% Unkown
HY-157176 BAX-IN-1 Inhibitor ≥98.0% Unkown
HY-147889 BBR-BODIPY Activator 98.15% Unkown
HY-N1157 Thevetiaflavone Modulator ≥98.0% Unkown
HY-147929 Apoptotic agent-3 Activator / Unkown
HY-N0831R Jaceosidin (Standard) Activator / Unkown
HY-N10313 Dehydrobruceine B Modulator / Unkown
HY-162360 EGFR-IN-109 Inhibitor / Unkown
HY-147928 Apoptotic agent-2 Activator / Unkown
HY-P3148 Astin B Modulator / Unkown
HY-143235 BRD4 Inhibitor-15 Modulator / Unkown
HY-144791 Bcl-2-IN-6 Modulator / Unkown
HY-146548 Anticancer agent 43 Inducer 98.58% Unkown
HY-147514 Anticancer agent 64 Modulator / Unkown
HY-146253 CDK1/2/4-IN-1 Activator / Unkown
HY-146105 Anticancer agent 65 Modulator / Unkown
HY-101996 SMBA1 Agonist / Unkown
HY-144792 Bcl-2-IN-7 Modulator / Unkown
HY-151428 Antitumor agent-78 Inhibitor / Unkown
HY-117652 Lobetyol Modulator / Unkown
HY-151429 Antitumor agent-77 Inhibitor / Unkown
HY-N10481 Aviculin Modulator / Unkown
HY-150540 Bcl-2-IN-10 Inhibitor / Unkown
HY-148368 CYD-4-61 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bax NCBI NCBI:581