CLNS1A - chloride nucleotide-sensitive channel 1A Gene

Homo sapiens

Also known as CLCI; ICln; CLNS1B

Gene ID: 1207 | Gene type: protein coding

About CLNS1A

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:77,614,530-77,637,794 (from NCBI)

This gene has 12 transcripts (splice variants) and 239 orthologues. Ubiquitous expression in adrenal (RPKM 36.6), brain (RPKM 32.8) and 25 other tissues.

Summary

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

CLNS1A Products(5)

mRNA	Protein	Name
NM_001293.3	NP_001284.1	methylosome subunit pICln isoform a
NM_001311199.2	NP_001298128.1	methylosome subunit pICln isoform a
NM_001311200.2	NP_001298129.1	methylosome subunit pICln isoform b
NM_001311201.2	NP_001298130.1	methylosome subunit pICln isoform c
NM_001311202.2	NP_001298131.1	methylosome subunit pICln isoform d

CLNS1A Protein Structure

Voldacs

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

methylosome subunit pICln

chloride channel regulatory protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02827	CLNS1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLNS1A	VGNC	VGNC:82000
Macaca mulatta	CLNS1A	VGNC	VGNC:71261
Bos taurus	CLNS1A	VGNC	VGNC:27455
Mus musculus	CLNS1A	MGD	MGI:109638
Rattus norvegicus	CLNS1A	RGD	RGD:61884

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