2. Gene
  3. GPR139 - G protein-coupled receptor 139 Gene

GPR139 - G protein-coupled receptor 139 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PGR3; GPRg1

Gene ID: 124274 | Gene type: protein coding

About GPR139

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,028,239-20,073,890 (from NCBI)

This gene has 2 transcripts (splice variants), 335 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GPR139 Products(2)

mRNA Protein Name
NM_001002911.4 NP_001002911.1 probable G-protein coupled receptor 139 isoform 1
NM_001318483.1 NP_001305412.1 probable G-protein coupled receptor 139 isoform 2

GPR139 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 285)

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  • 353 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 139

G protein-coupled receptor PGR3

g(q)-coupled orphan receptor GPRg1

Related Diseases

Diseases Alias
Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib

IGHD1B

Ighd Ib

Growth Hormone Deficiency, Isolated, Type Ib

Congenital Ighd Type Ib

Congenital Isolated Gh Deficiency Type Ib

Congenital Isolated Growth Hormone Deficiency Type Ib

Dwarfism Of Sindh

Pituitary Dwarfism I

Isolated Growth Hormone Deficiency Type 1b

Ighd 1b

Growth Hormone Deficiency, Isolated, 1b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132228 Zelatriazin Agonist 99.89% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19838 JNJ-63533054 Agonist 99.90% Unkown
HY-128057 NCRW0005-F05 Antagonist ≥99.0% Unkown
HY-119168 LP-471756 Antagonist 99.69% Unkown
HY-101777 TC-O 9311 Agonist 99.70% Unkown
HY-149651 GPR139 agonist-2 Agonist 99.80% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPR139 VGNC VGNC:41400
Macaca mulatta GPR139 VGNC VGNC:104730
Rattus norvegicus GPR139 RGD RGD:1311729
Mus musculus GPR139 MGD MGI:2685341
Felis catus GPR139 VGNC VGNC:80578
Bos taurus GPR139 VGNC VGNC:29553