ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

Homo sapiens

Also known as ADH-2; HEL-S-4

Gene ID: 127 | Gene type: protein coding

About ADH4

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,123,658-99,144,297 (from NCBI)

This gene has 11 transcripts (splice variants), 346 orthologues and 17 paralogues. Restricted expression toward liver (RPKM 940.8).

Summary

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this Enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

ADH4 Products(3)

mRNA	Protein	Name
NM_000670.5	NP_000661.2	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 2
NM_001306171.2	NP_001293100.1	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1
NM_001306172.2	NP_001293101.1	all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1

ADH4 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

all-trans-retinol dehydrogenase [NAD(+)] ADH4

alcohol dehydrogenase class II pi chain

Related Diseases

Diseases

Alias

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Cluster Headache

Headache, Cluster

Hypocalciuric Hypercalcemia, Familial, Type Ii

HHC2	Familial Hypocalciuric Hypercalcemia 2
Fbh2	Familial Hypocalciuric Hypercalcemia Type 2
Hypocalciuric Hypercalcemia, Type Ii	Fhh Type 2
Familial Benign Hypercalcemia, Type Ii	Hypercalcemia, Familial Benign, Type Ii
Hypocalciuric Hypercalcemia Type Ii	Familial Benign Hypercalcemia, Type 2
Hypercalcemia, Familial Benign Type 2	Hypocalciuric Hypercalcemia, Familial, Type 2
Hypocalciuric Hypercalcemia, Familial 2	Familial Benign Hypercalcemia Type Ii
Hypocalciuric Hypercalcemia-2

Hypocalciuric Hypercalcemia, Familial, Type I

HHC1	Familial Hypocalciuric Hypercalcemia 1
Fhh1	Familial Benign Hypercalcemia 1
Fbh1	Hypocalciuric Hypercalcemia, Type I
Fhh Type 1	Hhc
Fhh	Hypercalcemia, Familial Benign
Hypocalciuric Hypercalcemia Type I	Familial Hypocalciuric Hypercalcemia Type 1
Hypocalciuric Hypercalcemia, Familial, Type 1	Familial Hypocalciuric Hypercalcemia Type I
Familial Benign Hypercalcemia Type 1	Hypercalcemia, Familial Benign Type 1
Hypocalciuric Hypercalcemia, Familial 1	Familial Benign Hypocalciuric Hypercalcemia 1
Fbhh1

Substance Dependence

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia	Fbh
Fbhh	Fhh
Familial Benign Hypocalciuric Hypercalcemia	Hypocalciuric Hypercalcemia, Familial, Type 1

Headache

Headache Disorder

Hypocalcemia, Autosomal Dominant 1

Autosomal Dominant Hypocalcemia	Autosomal Dominant Hypocalcemia 1
HYPOC1	Hypocalcemia, Autosomal Dominant
Hypercalciuric Hypocalcemia	Hypocalcemia, Autosomal Dominant, With Bartter Syndrome
Familial Hypocalcemia	Hypocalcemia, Familial
Hypoc	Adh
Autosomal Dominant Hypoparathyroidism	Familial Hypercalciuric Hypocalcemia
Ad Hypocalcemia	Autosomal Dominant Hypocalcemia With Bartter Syndrome
Hypoparathyroidism - Autosomal Dominant	Hypocalcemia

Familial Isolated Hypoparathyroidism

Fih

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00369	ADH4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADH4	RGD	RGD:71028
Mus musculus	ADH4	MGD	MGI:1349472