Ccr1 - chemokine (C-C motif) receptor 1 Gene

Mus musculus

Also known as Cmkbr1; Mip-1a-R

Gene ID: 12768 | Gene type: protein coding

About Ccr1

Chromosome 9: 123,762,161-123,768,729 reverse strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 151 orthologues, 25 paralogues and is associated with 44 phenotypes. Broad expression in liver E18 (RPKM 2.5), large intestine adult (RPKM 2.2) and 23 other tissues.

Summary

Enables C-C Chemokine Receptor activity. Involved in negative regulation of innate immune response. Acts upstream of or within inflammatory response; leukocyte chemotaxis; and myeloid cell differentiation. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including dorsal aorta; extraembryonic component; limb; liver; and urogenital ridge. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ccr1 Products(1)

mRNA	Protein	Name
NM_009912.4	NP_034042.3	C-C chemokine receptor type 1

Ccr1 Protein Structure

7tmA_CCR1

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 1

C-C CKR-1	CC-CKR-1
CCR-1	MIP-1 alpha R
MIP-1 alphaR	MIP-1alpha-R
RANTES-R	chemokine (C-C) receptor 1
macrophage inflammatory protein 1-alpha receptor

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00350	CCX354	Antagonist	99.18%	Phase 2
HY-120588	BI 639667	Antagonist	99.47%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12080	BX471	Antagonist	99.94%	Unkown
HY-18611	RS102895 hydrochloride	Antagonist	99.87%	Unkown
HY-12080A	BX471 hydrochloride	Antagonist	99.94%	Unkown
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-18611A	RS102895	Antagonist	99.97%	Unkown
HY-124759	CCR1 antagonist 9	Antagonist	99.93%	Unkown
HY-103355	YM022	Antagonist	99.93%	Unkown
HY-15546	BMS-817399	Antagonist	99.83%	Unkown
HY-15544	CCR1 antagonist 10	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr1	NCBI	NCBI:1230

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