2. Gene
  3. ADH5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

ADH5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FDH; ADHX; ADH-3; AMEDS; BMFS7; FALDH; GSNOR; GSH-FDH; HEL-S-60p

Gene ID: 128 | Gene type: protein coding

About ADH5

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,070,978-99,088,788 (from NCBI)

This gene has 13 transcripts (splice variants), 391 orthologues, 17 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues.

Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This Enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

ADH5 Products(1)

mRNA Protein Name
NM_000671.4 NP_000662.3 alcohol dehydrogenase class-3

ADH5 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (33 - 159)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (202 - 323)

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  • 374 a.a.
Protein Preferred Names Protein Names

alcohol dehydrogenase class-3

S-(hydroxymethyl)glutathione dehydrogenase

S-nitrosoglutathione reductase

alcohol dehydrogenase (class III), chi polypeptide

alcohol dehydrogenase class chi chain

alcohol dehydrogenase class-III

epididymis secretory sperm binding protein Li 60p

formaldehyde dehydrogenase

glutathione-dependent formaldehyde dehydrogenase

Related Diseases

Diseases Alias
Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact
Thyroid Dyshormonogenesis 3

TDH3

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3

Thyroid Hormonogenesis, Genetic Defect In, 3

Genetic Defect In Thyroid Hormonogenesis 3

Chdh3

Congenital Hypothyroidism Due To Dyshormonogenesis Type 3

Genetic Defect In Thyroid Hormonogenesis Type 3
Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter
Proliferative Type Fibrocystic Change Of Breast

Fibrocystic Change, Proliferative Type With Atypia

Fibrocystic Disease, Proliferative Type With Atypia

Proliferating Lesion Of Breast Without Atypia

Proliferating Lesion Of The Breast Without Atypia

Proliferative Fibrocystic Change

Breast Fibrocystic Change, Proliferative Type
Breast Intraductal Proliferative Lesion

Intraductal Proliferative Lesion

Intraductal Proliferative Lesion Of The Breast
Pharyngitis

Acute Pharyngitis

Chronic Pharyngitis

Acute Sore Throat

Chronic Sore Throat

Persistent Sore Throat

Pharyngeal Diseases

Chronic Pharyn/Nasopharyngitis

Chronic Pharyngitis And Nasopharyngitis

Inflamed Throat

Pharyngeal Disease

Pharyngeal Disorder

Pharyngitis - Acute

Sore Throat - Chronic

Acute Pharyngitis Nos

Acute Sore Throat Nos

Acute Throat Inflammation

Infective Pharyngitis

Infection Of Pharynx

Acute Infective Pharyngitis

Acute Infective Pharyngitis Nos

Acute Pharyngeal Inflammation

Inflammation Of The Throat

Throat Inflammation

Throat Infection

Putrid Pharyngitis

Pharyngeal Inflammation

Pharyngitis Nos

Chronic Throat Pain

Throat Catarrh
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Substance Dependence
Amed Syndrome, Digenic

Amed Syndrome

AMEDS

Bone Marrow Failure Syndrome 7, Digenic

Bmfs7

Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Focal Dermal Hypoplasia

Goltz Syndrome

Goltz-Gorlin Syndrome

FDH

FODH

Dhof

Goltz Gorlin Syndrome

Hypoplasia, Dermal, Focal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00370 ADH5 Human Pre-designed siRNA Set A / Unkown
HY-RS00371 Adh5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00372 Adh5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADH5 MGD MGI:87929