2. Gene
  3. Cnr1 - cannabinoid receptor 1 (brain) Gene

Cnr1 - cannabinoid receptor 1 (brain) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CB1; CB-R; CB1A; CB1B; CB1R

Gene ID: 12801 | Gene type: protein coding

About Cnr1

Chromosome 4: 33,924,593-33,948,831 forward strand.GRCm39:CM000997.3

This gene has 3 transcripts (splice variants), 206 orthologues, 18 paralogues and is associated with 83 phenotypes. Biased expression in cerebellum adult (RPKM 24.), CNS E18 (RPKM 17.4) and 7 other tissues.

Summary

Enables Cannabinoid Receptor activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in cannabinoid signaling pathway; retrograde trans-synaptic signaling by endocannabinoid; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in several cellular components, including GABA-ergic synapse; growth cone; and presynaptic membrane. Is integral component of mitochondrial membrane and integral component of presynaptic membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (Cannabinoid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnr1 Products(4)

mRNA Protein Name
NM_007726.5 NP_031752.1 cannabinoid receptor 1
NM_001355021.2 NP_001341950.1 cannabinoid receptor 1
NM_001355020.2 NP_001341949.1 cannabinoid receptor 1
NM_001365881.1 NP_001352810.1 cannabinoid receptor 1

Cnr1 Protein Structure

7tmA_CB1

7tmA_CB1: cd15340 (117 - 408)

7tmA_CB1

7tmA_CB1: cd15340 (118 - 144)

7tmA_CB1

7tmA_CB1: cd15340 (152 - 177)

7tmA_CB1

7tmA_CB1: cd15340 (189 - 219)

7tmA_CB1

7tmA_CB1: cd15340 (231 - 251)

7tmA_CB1

7tmA_CB1: cd15340 (271 - 300)

7tmA_CB1

7tmA_CB1: cd15340 (336 - 366)

7tmA_CB1

7tmA_CB1: cd15340 (376 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

cannabinoid receptor 1

brain-type cannabinoid receptor

striatal cannabinoid receptor type 1 protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02914 CNR1 Human Pre-designed siRNA Set A / Unkown
HY-RS02915 Cnr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS02916 Cnr1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnr1 NCBI NCBI:1268
Rattus norvegicus Cnr1 NCBI NCBI:25248