DUSP15 - dual specificity phosphatase 15 Gene

Homo sapiens

Also known as VHY; C20orf57

Gene ID: 128853 | Gene type: protein coding

About DUSP15

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,845,593-31,870,664 (from NCBI)

This gene has 10 transcripts (splice variants), 109 orthologues and 30 paralogues. Biased expression in testis (RPKM 10.5), kidney (RPKM 3.2) and 1 other tissue.

Summary

The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific Phosphatase activity, and therefore is known as a dual specificity Phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

DUSP15 Products(5)

mRNA	Protein	Name
NM_001012644.3	NP_001012662.1	dual specificity protein phosphatase 15 isoform b
NM_001320478.1	NP_001307407.1	dual specificity protein phosphatase 15 isoform c
NM_001320479.1	NP_001307408.1	dual specificity protein phosphatase 15 isoform d
NM_080611.5	NP_542178.2	dual specificity protein phosphatase 15 isoform a
NM_177991.3	NP_817130.1	dual specificity protein phosphatase 15 isoform b

DUSP15 Protein Structure

DSPc

0
100
200
295 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 15

VH1-related member Y

Related Diseases

Diseases

Alias

Nanophthalmos

Nanophthalmia

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04056	DUSP15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DUSP15	VGNC	VGNC:50028
Canis familiaris	DUSP15	VGNC	VGNC:103673
Mus musculus	DUSP15	MGD	MGI:1934928
Felis catus	DUSP15	VGNC	VGNC:61663
Rattus norvegicus	DUSP15	RGD	RGD:1305990
Macaca mulatta	DUSP15	VGNC	VGNC:71848

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