Crhr1 - corticotropin releasing hormone receptor 1 Gene

Mus musculus

Also known as Crhr; CRF1R; CRFR1

Gene ID: 12921 | Gene type: protein coding

About Crhr1

Biased expression in cerebellum adult (RPKM 7.7), frontal lobe adult (RPKM 4.7) and 6 other tissues.

Summary

The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates Adenylate Cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Crhr1 Products(3)

mRNA	Protein	Name
NM_007762.5	NP_031788.1	corticotropin-releasing factor receptor 1 isoform 1 precursor
NM_001313929.1	NP_001300858.1	corticotropin-releasing factor receptor 1 isoform 3
NM_001313928.1	NP_001300857.1	corticotropin-releasing factor receptor 1 isoform 2 precursor

Crhr1 Protein Structure

HormR

7tmB1_CRF-R1

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

corticotropin-releasing factor receptor 1

CRF 1 receptor	CRF-R-1
CRF-R1	CRF-R1alpha
CRFR-1	CRH-R-1
CRH-R1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103377	Antalarmin hydrochloride	Antagonist	99.87%	Unkown
HY-12131	DMP 696	Antagonist	99.03%	Unkown
HY-124475	Antalarmin	Antagonist	/	Unkown
HY-RS03168	CRHR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03169	Crhr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03170	Crhr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crhr1	NCBI	NCBI:1394

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