LYPD6 - LY6/PLAUR domain containing 6 Gene

Homo sapiens

Gene ID: 130574 | Gene type: protein coding

About LYPD6

Cytogenetic location: 2q23.2 Genomic coordinates (GRCh38): 2:149,329,985-149,486,378 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 1 paralogue. Biased expression in gall bladder (RPKM 7.3), placenta (RPKM 6.8) and 12 other tissues.

Summary

Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]

LYPD6 Products(2)

mRNA	Protein	Name
NM_001195685.2	NP_001182614.1	ly6/PLAUR domain-containing protein 6 precursor
NM_194317.5	NP_919298.1	ly6/PLAUR domain-containing protein 6 precursor

Protein Preferred Names

Protein Names

ly6/PLAUR domain-containing protein 6

Related Diseases

Diseases

Alias

Mal De Meleda

Meleda Disease	Keratosis Palmoplantaris Transgrediens Of Siemens
MDM	Transgrediens Palmoplantar Keratoderma Of Siemens
Acroerythrokeratoderma	Keratosis Palmoplantaris Transgradiens Of Siemens

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07918	LYPD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07919	LYPD6B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LYPD6	VGNC	VGNC:80272
Bos taurus	LYPD6	VGNC	VGNC:31103
Rattus norvegicus	LYPD6	RGD	RGD:1587119
Canis familiaris	LYPD6	VGNC	VGNC:42888
Mus musculus	LYPD6	MGD	MGI:2443848
Macaca mulatta	LYPD6	VGNC	VGNC:99377

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