2. Gene
  3. Drd1 - dopamine receptor D1 Gene

Drd1 - dopamine receptor D1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Drd-1; Drd1a; Gpcr15; C030036C15Rik

Gene ID: 13488 | Gene type: protein coding

About Drd1

Chromosome 13: 54,205,202-54,209,724 reverse strand.GRCm39:CM001006.3

This gene has 3 transcripts (splice variants), 262 orthologues, 32 paralogues and is associated with 37 phenotypes. Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.8) and 5 other tissues.

Summary

Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in modification of postsynaptic structure and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including GABA-ergic synapse; dendritic spine; and glutamatergic synapse. Is integral component of presynaptic membrane. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (Dopamine Receptor D1). [provided by Alliance of Genome Resources, Apr 2022]

Drd1 Products(2)

mRNA Protein Name
NM_010076.3 NP_034206.1 D(1A) dopamine receptor
NM_001291801.1 NP_001278730.1 D(1A) dopamine receptor

Drd1 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (21 - 340)

7tm_GPCRs

7tm_GPCRs: cd14964 (24 - 48)

7tm_GPCRs

7tm_GPCRs: cd14964 (58 - 80)

7tm_GPCRs

7tm_GPCRs: cd14964 (95 - 117)

7tm_GPCRs

7tm_GPCRs: cd14964 (140 - 156)

7tm_GPCRs

7tm_GPCRs: cd14964 (191 - 214)

7tm_GPCRs

7tm_GPCRs: cd14964 (270 - 292)

7tm_GPCRs

7tm_GPCRs: cd14964 (309 - 334)

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  • 446 a.a.
Protein Preferred Names Protein Names

D(1A) dopamine receptor

D1 receptor

D1A dopamine receptor

G protein-coupled receptor DRD1

dopamine D1 receptor

dopamine receptor D1A

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03994 DRD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03995 Drd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03996 Drd1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drd1 NCBI NCBI:1812