LRGUK - leucine rich repeats and guanylate kinase domain containing Gene

Homo sapiens

Also known as CFAP246

Gene ID: 136332 | Gene type: protein coding

About LRGUK

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,127,340-134,276,685 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 13 paralogues. Biased expression in testis (RPKM 1.3), lung (RPKM 0.2) and 7 other tissues.

Summary

Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LRGUK Products(4)

mRNA	Protein	Name
NM_001365700.3	NP_001352629.1	leucine-rich repeat and guanylate kinase domain-containing protein isoform 1
NM_001365701.3	NP_001352630.1	leucine-rich repeat and guanylate kinase domain-containing protein isoform 2
NM_001401519.1	NP_001388448.1	leucine-rich repeat and guanylate kinase domain-containing protein isoform 4
NM_144648.3	NP_653249.1	leucine-rich repeat and guanylate kinase domain-containing protein isoform 3

LRGUK Protein Structure

LRR_9

Guanylate_kin

0
200
400
600
825 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat and guanylate kinase domain-containing protein

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07785	LRGUK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LRGUK	VGNC	VGNC:74334
Mus musculus	LRGUK	MGD	MGI:1921604
Felis catus	LRGUK	VGNC	VGNC:63279
Rattus norvegicus	LRGUK	RGD	RGD:1308226
Bos taurus	LRGUK	VGNC	VGNC:52794
Canis familiaris	LRGUK	VGNC	VGNC:54786

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