ASB7 - ankyrin repeat and SOCS box containing 7 Gene

Homo sapiens

Gene ID: 140460 | Gene type: protein coding

About ASB7

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:100,602,589-100,651,701 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 4.8), thyroid (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ASB7 Products(2)

mRNA	Protein	Name
NM_024708.4	NP_078984.2	ankyrin repeat and SOCS box protein 7 isoform 1
NM_198243.3	NP_937886.1	ankyrin repeat and SOCS box protein 7 isoform 2

ASB7 Protein Structure

Ank_2

SOCS_box

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 7

ASB-7

Related Diseases

Diseases

Alias

Lipase Deficiency, Combined

Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency	Lpl And Htgl Deficiency
Lpl And Hl Deficiency	Familial Lipase Maturation Factor 1 Deficiency
Lipase Deficiency Combined	Combined Lipase Deficiency
Familial Lmf1 Deficiency	CLD

Isolated Microphthalmia

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Short-Rib Thoracic Dysplasia 9 With Or Without Polydactyly

Conorenal Syndrome	Saldino-Mainzer Syndrome
SRTD9	Mainzer-Saldino Syndrome
Mzsds	Mainzer-Saldino Disease
Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia, And Skeletal Dysplasia	Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dysplasia
Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dy	Mainzer Saldino Syndrome
Conorenal Dysplasia	Mainzer-Saldino Chondrodysplasia
Saldino-Mainzer Dysplasia	Short-Rib Thoracic Dysplasia 9
Renal Dysplasia-Retinal Pigmentary Dystrophy-Cerebellar Ataxia-Skeletal Dysplasia Syndrome	Mss
Renal Dysplasia Retinal Pigmentary Dystrophy Cerebellar Ataxia And Skeletal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01072	ASB7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ASB7	VGNC	VGNC:59963
Canis familiaris	ASB7	VGNC	VGNC:38167
Bos taurus	ASB7	VGNC	VGNC:26200
Rattus norvegicus	ASB7	RGD	RGD:1305154
Mus musculus	ASB7	MGD	MGI:2152835
Macaca mulatta	ASB7	VGNC	VGNC:69851