2. Gene
  3. Cdk5 - cyclin-dependent kinase 5 Gene

Cdk5 - cyclin-dependent kinase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 140908 | Gene type: protein coding

About Cdk5

Primary_assembly 4: 10,754,687-10,760,112 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 170 orthologues, 24 paralogues and is associated with 16 phenotypes. Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 12.7) and 9 other tissues.

Summary

Enables several functions, including Ephrin Receptor binding activity; protein kinase activity; and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 Products(1)

mRNA Protein Name
NM_080885.2 NP_543161.1 cyclin-dependent kinase 5

Cdk5 Protein Structure

STKc_CDK5

STKc_CDK5: cd07839 (2 - 285)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 5

TPKII catalytic subunit

cell division protein kinase 5

cyclin-dependent-like kinase 5

serine/threonine-protein kinase PSSALRE

tau protein kinase II catalytic subunit

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.96% Yes
HY-10492 Dinaciclib Inhibitor 99.44% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-30237 (R)-Roscovitine Inhibitor 99.84% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.87% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
Bioactive Molecules (53)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12302 Kenpaullone Inhibitor 98.16% Unkown
HY-15154 NG 52 Inhibitor 99.97% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-10014 R547 Inhibitor 99.57% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 98.06% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.21% Unkown
HY-18299A Purvalanol A Inhibitor 98.30% Unkown
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.78% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-18299 Purvalanol B Inhibitor ≥97.0% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% Unkown
HY-W011428 Olomoucine Inhibitor 99.78% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-144117 GFB-12811 Inhibitor 98.00% Unkown
HY-107419 NU6140 Inhibitor 99.07% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-108359 Alsterpaullone Inhibitor 98.38% Unkown
HY-145694 CDK5-IN-3 Inhibitor 98.00% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-103221 MeBIO Inhibitor ≥98.0% Unkown
HY-154851 GSK-3 inhibitor 3 Inhibitor 98.72% Unkown
HY-117025A Manzamine A hydrochloride Inhibitor 99.66% Unkown
HY-121035 7BIO Inhibitor ≥98.0% Unkown
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% Unkown
HY-112358 GW8510 Inhibitor 99.64% Unkown
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-136726 CGP-82996 Inhibitor / Unkown
HY-14372 BS-194 Inhibitor 99.36% Unkown
HY-103381 NSC693868 Inhibitor ≥99.0% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor / Unkown
HY-13461 PHA-767491 Inhibitor / Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-112336 Aloisine RP106 Inhibitor / Unkown
HY-139725 CDK5-IN-1 Inhibitor / Unkown
HY-117025 Manzamine A Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-154852 GSK-3 inhibitor 4 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-145693 CDK5-IN-2 Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor / Unkown
HY-103383 (R)-DRF053 dihydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk5 NCBI NCBI:1020