MIB2 - MIB E3 ubiquitin protein ligase 2 Gene

Homo sapiens

Also known as ZZZ5; ZZANK1

Gene ID: 142678 | Gene type: protein coding

About MIB2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,613,731-1,630,605 (from NCBI)

This gene has 32 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]

MIB2 Products(5)

mRNA	Protein	Name
NM_001170686.4	NP_001164157.3	E3 ubiquitin-protein ligase MIB2 isoform 2
NM_001170687.4	NP_001164158.3	E3 ubiquitin-protein ligase MIB2 isoform 1
NM_001170688.2	NP_001164159.2	E3 ubiquitin-protein ligase MIB2 isoform 4
NM_001170689.2	NP_001164160.1	E3 ubiquitin-protein ligase MIB2 isoform 5
NM_080875.5	NP_543151.4	E3 ubiquitin-protein ligase MIB2 isoform 1

MIB2 Protein Structure

MIB_HERC2

Ank_5

Ank_2

Ank_4

Ank_2

zf-C3HC4_3

0
200
400
600
800
1000
1070 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MIB2

RING-type E3 ubiquitin transferase MIB2

Related Diseases

Diseases

Alias

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type	Alport Syndrome, Autosomal Recessive
Alport Syndrome Autosomal Recessive	Alport Syndrome Recessive Type
Nephropathy And Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08423	MIB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIB2	MGD	MGI:2679684
Rattus norvegicus	MIB2	RGD	RGD:1359469
Macaca mulatta	MIB2	VGNC	VGNC:74627
Felis catus	MIB2	VGNC	VGNC:80282
Canis familiaris	MIB2	VGNC	VGNC:43218
Bos taurus	MIB2	VGNC	VGNC:31456