NFAM1 - NFAT activating protein with ITAM motif 1 Gene

Homo sapiens

Also known as CNAIP

Gene ID: 150372 | Gene type: protein coding

About NFAM1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,380,407-42,437,986 (from NCBI)

This gene has 2 transcripts (splice variants) and 97 orthologues. Broad expression in bone marrow (RPKM 10.9), appendix (RPKM 7.1) and 16 other tissues.

Summary

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]

NFAM1 Products(3)

mRNA	Protein	Name
NM_001318323.3	NP_001305252.1	NFAT activation molecule 1 isoform 2 precursor
NM_001371362.1	NP_001358291.1	NFAT activation molecule 1 isoform 3
NM_145912.8	NP_666017.1	NFAT activation molecule 1 isoform 1 precursor

Protein Preferred Names

Protein Names

NFAT activation molecule 1

calcineurin/NFAT-activating ITAM-containing protein

Related Diseases

Diseases

Alias

Klippel-Feil Syndrome 4

Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria	Polymicrogyria, Bilateral Perisylvian
Pmgx	Perisylvian Syndrome, Congenital Bilateral
Cbps	Congenital Bilateral Perisylvian Syndrome
Perisylvian Syndrome	BPPX
Bpp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09235	NFAM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NFAM1	VGNC	VGNC:82493
Rattus norvegicus	NFAM1	RGD	RGD:1308316
Mus musculus	NFAM1	MGD	MGI:1921289
Bos taurus	NFAM1	VGNC	VGNC:32027
Macaca mulatta	NFAM1	VGNC	VGNC:75279
Canis familiaris	NFAM1	VGNC	VGNC:43763

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