Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

Mus musculus

Also known as 5-HT4; 5HTR4; 5-HT-4; 5-HT

Gene ID: 15562 | Gene type: protein coding

About Htr4

Chromosome 18: 62,457,275-62,629,648 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 201 orthologues, 32 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues.

Summary

Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Htr4 Products(5)

mRNA	Protein	Name
NM_001364959.1	NP_001351888.1	5-hydroxytryptamine receptor 4 isoform 5
NM_001364956.1	NP_001351885.1	5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1	NP_001351886.1	5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1	NP_001351887.1	5-hydroxytryptamine receptor 4 isoform 4
NM_008313.4	NP_032339.2	5-hydroxytryptamine receptor 4 isoform 1

Htr4 Protein Structure

7tmA_5-HT4

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 4

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14153A	Tegaserod maleate		99.93%	Unkown
HY-14153	Tegaserod		99.89%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06474	HTR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06475	Htr4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06476	Htr4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14153S	Tegaserod-d11		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr4	NCBI	NCBI:3360

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