DBN1 - drebrin 1 Gene

Homo sapiens

Also known as D0S117E

Gene ID: 1627 | Gene type: protein coding

About DBN1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,456,610-177,473,634 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 21.1), brain (RPKM 16.5) and 24 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DBN1 Products(7)

mRNA	Protein	Name
NM_001363541.2	NP_001350470.2	drebrin isoform c
NM_001364151.2	NP_001351080.2	drebrin isoform d
NM_001364152.2	NP_001351081.2	drebrin isoform e
NM_001393630.1	NP_001380559.1	drebrin isoform f
NM_001393631.1	NP_001380560.1	drebrin isoform g
NM_004395.4	NP_004386.3	drebrin isoform a
NM_080881.3	NP_543157.2	drebrin isoform b

DBN1 Protein Structure

Cofilin_ADF

0
100
200
300
400
500
600
649 a.a.

Protein Preferred Names

Protein Names

drebrin

developmentally-regulated brain protein

Related Diseases

Diseases

Alias

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Dyskeratosis Congenita, Autosomal Recessive 2

DKCB2	Autosomal Recessive Dyskeratosis Congenita 2
Dyskeratosis Congenita, Autosomal Recessive, 2	Dyskeratosis Congenita, Autosomal Recessive, Type 2

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03548	DBN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DBN1	VGNC	VGNC:61347
Canis familiaris	DBN1	VGNC	VGNC:39783
Bos taurus	DBN1	VGNC	VGNC:27890
Rattus norvegicus	DBN1	RGD	RGD:70885
Mus musculus	DBN1	MGD	MGI:1931838
Macaca mulatta	DBN1	VGNC	VGNC:71742