GBP6 - guanylate binding protein family member 6 Gene

Homo sapiens

Gene ID: 163351 | Gene type: protein coding

About GBP6

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,364,059-89,388,160 (from NCBI)

This gene has 1 transcript (splice variant), 281 orthologues and 10 paralogues. Restricted expression toward esophagus (RPKM 171.0).

Summary

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GBP6 Products(2)

mRNA	Protein	Name
NM_001320257.2	NP_001307186.1	guanylate-binding protein 6 isoform 2
NM_198460.3	NP_940862.2	guanylate-binding protein 6 isoform 1

GBP6 Protein Structure

GBP

GBP_C

0
100
200
300
400
500
633 a.a.

Protein Preferred Names

Protein Names

guanylate-binding protein 6

GBP-6

Related Diseases

Diseases

Alias

Noonan Syndrome 6

NS6	Noonan Syndrome, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05312	GBP6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GBP6	RGD	RGD:1561523
Canis familiaris	GBP6	VGNC	VGNC:41134
Macaca mulatta	GBP6	VGNC	VGNC:104705