Sgk3 - serum/glucocorticoid regulated kinase 3 Gene

Mus musculus

Also known as fy; fz; Cisk; 2510015P22Rik; A330005P07Rik

Gene ID: 170755 | Gene type: protein coding

About Sgk3

Chromosome 1: 9,868,332-9,971,070 forward strand.GRCm39:CM000994.3

This gene has 12 transcripts (splice variants), 212 orthologues, 13 paralogues and is associated with 44 phenotypes. Broad expression in placenta adult (RPKM 7.), liver E14 (RPKM 4.9) and 19 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to several human genes including C8orf44-SGK3 (C8orf44-SGK3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Sgk3 Products(3)

mRNA	Protein	Name
NM_133220.2	NP_573483.1	serine/threonine-protein kinase Sgk3
NM_001037759.1	NP_001032848.1	serine/threonine-protein kinase Sgk3
NM_177547.3	NP_808215.2	serine/threonine-protein kinase Sgk3

Sgk3 Protein Structure

PX_CISK

STKc_SGK3

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Sgk3

cytokine-independent survival kinase

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125878	PROTAC SGK3 degrader-1	Inhibitor	99.02%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sgk3	NCBI	NCBI:23678