Mc1r - melanocortin 1 receptor Gene

Mus musculus

Also known as e; Tob; Mcr1; Mshra

Gene ID: 17199 | Gene type: protein coding

About Mc1r

Chromosome 8: 124,133,846-124,137,483 forward strand.GRCm39:CM001001.3

This gene has 1 transcript (splice variant), 156 orthologues, 18 paralogues and is associated with 20 phenotypes.

Summary

Enables melanocyte-stimulating hormone receptor activity. Involved in intracellular signal transduction; positive regulation of intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within melanin biosynthetic process; pigmentation; and sensory perception of pain. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; and skin. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc1r Products(1)

mRNA	Protein	Name
NM_008559.3	NP_032585.2	melanocyte-stimulating hormone receptor

Mc1r Protein Structure

7tm_GPCRs

0
100
200
315 a.a.

Protein Preferred Names

Protein Names

melanocyte-stimulating hormone receptor

MC1-R	MSH-R
extension recessive yellow	melanocortin receptor 1
tobacco darkening

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2466	Melanotan I	Agonist	99.75%	Unkown
HY-N2466A	Melanotan I acetate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147301	Resomelagon	Agonist	99.63%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P1545A	ACTH (1-17) (TFA)	Agonist	99.85%	Unkown
HY-P99004	hMC1R agonist 1	Antagonist	/	Unkown
HY-P1726A	MSG606 TFA	Antagonist	/	Unkown
HY-P0097	Nonapeptide-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc1r	NCBI	NCBI:4157

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